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interesting discussion. when we use this stuff at the bedside, we don't use "raw" NNTs and NNHs, and don't make a simple comparison between them. rather, we adjust both the NNT and the NNH for the patient's unique biology and then bring in a 3rd key element: the patient's values for the alternative states. sharon straus has led this work and can do it in about 6 minutes on our busy service. she's presented this at several meetings and has a Ms under review. cheers dls ............................................................................ Prof David L. Sackett Director, NHS R&D Centre for Evidence-Based Medicine Consultant in Medicine Editor, Evidence-Based Medicine Nuffield Department of Medicine, University of Oxford Level 5, John Radcliffe Hospital, Oxford OX3 9DU, England Phone: +44-(0)1865-221320 Fax: +44-(0)1865 222901 Email: [log in to unmask] WWW: http://cebm.jr2.ox.ac.uk ............................................................................ %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%