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Dear Thomas, what kind of stimulation did you use? Maybe your stimulation device produces more electrical noise to the scanner in the active condition than in the rest condition, increasing the mean intensity values. Than global normalisation by scaling will produce this effect. Michael. -- >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> Dr. Michael Erb Sektion f. experimentelle Kernspinresonanz des ZNS Abteilung Neuroradiologie Universitaetsklinikum Hoppe-Seyler_Str. 3, D-72076 Tuebingen Tel.: +49(0)7071/2985398 priv. +49(0)7071/61559 Fax.: +49(0)7071/294371 e-mail: <[log in to unmask]> www: http://www.medizin.uni-tuebingen.de/nrad/sektion <<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<< %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%