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Dear Paolo, > I have obtained with AIR a file .hdr, a file .img > I have a volume 256x256x256 > 8 bits/pixel > dim 1.16 1.16 1.16 > How can I make Talairach Normalization with SPM for WINDOWS 95 ? > > I tried a 'realignment' but it needs minimum two files. To realign, you need at least 2 images one reference image and one that you want to realign. Usually you have more than one volume that you want to realign. > About 'normalization' > Wich type of "template" is needed? Any image in the same modality can be used as a template. Usually a reference brain (eg MNI 305) is used. > Wich is the "image to estimate parameters"? That is the image you want to normalise. > If I can't make 'realignment' I can't generate mean_subject. You could generate a mean image even without realignment. Use the "Mean" button in SPM. A detailed description of image preprocessing and statistics can be found on http://www.fil.ion.ucl.ac.uk/spm. -Christian -- Dr. C. Buechel Research Fellow Functional Imaging Laboratory Wellcome Dept. of Cognitive Neurology 12 Queen Square WC1N 3BG London UK Tel.: +44-171-833-7483 Fax.: +44-171-813-1420 email: [log in to unmask] %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%