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Dear Luis, > SPM99b allows the user to display the raw time-course signal at a > particular voxel along with a plot of a particular regressor of > interest. It's a nice feature. > > Is there an easy way for SPM99b to display the time course of the raw > signal minus the estimated contributions from the regressors of no > interest? Yes there is. By using different F-contrasts or T-contrasts you specify the effects of interest. The remainder are treated as confounds and are removed from the adjusted data before plotting. This is why you get different plots with different contrasts. I hope this helps - Karl %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%