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Dear Chikashi, |Now I have a problem in normalisation. |I realigned the fM* images specifying Coregister&reslice => sinc |interpolation => mean image only. It was successful. I got rf*.imgs and |mean*.img. |Then I coregistered sM* structural image, with options as Coregister |only => target=sM*img(T1) => object=mean*.img(T2). Now this was successful, |I got rmean*.img. I think that the problem you are having is actually in the coregistration, which is then leading to problems normalising. Here's what I think is happening. You have realigned all the functional images together, so they are then in the same anatomical space. The structural image is initially in a different anatomical space. However you then coregister the mean functional to the structural (rather than the other way around) thus moving the rmean*.img into the anatomical space of the structural. As this space happens to be offset, when you normalise the s*.img you generate paramters that would correctly normalise the rmean*.img, but NOT the rfM*.img's, which are in a different anatomical space. The solution is to coregister the structural to the mean functionals (i.e. target = T2, object = T1) creating a rsM.img that you then normalise as you have done. This puts all the T2*, T1 and meanT2* images in the same anatomical space. Alternatively just normalise the mean*.img directly to the EPI template, bypassing the structural altogether. Good luck! best wishes, Geraint ----------------------------------------------------------------- Dr. Geraint Rees Wellcome Advanced Fellow Lecturer California Institute of Technology Institute of Neurology Division of Biology 139-74 University College London Pasadena 12 Queen Square California 91125 London WC1N 3BG voice (626) 395-2880 voice (171) 833-7472 fax (626) 796-8876 fax (171) 813-1420 [log in to unmask] ----------------------------------------------------------------- %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%