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> I have a sample of SPGRs that I am trying to analyse. I have found that > some scans, although appearing normal, become very "disfigured" following > spatial normalisation and therefore do not segment. Is there anything I can > do in terms of image preprocessing? Try SPM99b. The spatial normalization is much more stable. If you are already using SPM99b, then you can decrease the amount of distortion by increasing the amount of regularization via the "Defaults" button. Regards, -John %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%