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ST. BARTHOLOMEWS AND THE ROYAL LONDON SCHOOL OF MEDICINE AND DENTISTRY Department of Psychological Medicine Postdoctoral Research Assistant in Genetic Statistics Applications are invited for the above post to join a research group in the development of new statistical methods for mapping disease genes, especially those with complex inheritance. The group is led by Dr David Curtis and Dr Pak Sham. The successful candidate will be under the direct supervision of Dr Curtis and will be based at the Royal London Hospital, Whitechapel, in the East End of London. The initial main focus of the project will be to develop and implement new parameterisations of genetic models around the existing likelihood calculation engine of VITESSE or FASTLINK, two programs which carry out likelihood calculations of phenotypic and genotypic data from extended pedigrees. The aim of these parameterisations will be to allow likelihood maximisation over variables in a manner which is not feasible in the standard versions of these programs, in particular to implement developments from the MFLINK approach to genetic linkage analysis and to support fine-mapping using a combination of linkage and linkage disequilibrium analysis. Performance of new methods will be assessed by applying them to simulated data and to real data from projects the group is involved with, for example pertaining to schizophrenia, manic depression, coeliac disease, Tourette syndrome and ischaemic heart disease. It is expected that the post-holder will also provide general computing support to the group, including some data analysis and systems support. The applicant should be able to program in C and have training in statistics, preferably to a doctoral level. Experience in genetics and other computer-related skills would be advantageous. If the successful candidate does not possess a doctoral degree they would be expected to complete a PhD thesis as part of the project. Interested candidates are welcome to make informal contact with David Curtis (+44 171 377 7729, [log in to unmask]) and/or Pak Sham (+44 171 919 3534, [log in to unmask]). The post is funded for three years by a Wellcome project grant. Starting salary will be in the range of #17,869 to #23,949 pa inclusive of London Allowance. For further details and an application form please contact our 24 hour recruitment line on 0171-415-3737 or email: [log in to unmask] quoting reference number 99580/SK. Applications, quoting the reference number, should be returned by 31st August 1999 and be addressed to SMD Recruitment, Queen Mary and Westfield College, London E1 4NS. -- Dave Curtis Tel : +44-171-377-7729 Dept Adult Psychiatry Fax : +44-171-377-7316 3rd Floor Outpatient Building Email : [log in to unmask] Royal London Hospital WWW : http://www.gene.ucl.ac.uk/~dcurtis/ Whitechapel, London E1 1BB, UK %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%