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DIVISION OF STATISTICS AND OPERATIONAL RESEARCH DEPARTMENT OF MATHEMATICAL SCIENCES, UNIVERSITY OF LIVERPOOL All are welcome to attend. For more information please contact Paula Williamson at this email. ******************************************************************************** DATE: Wednesday 28 July TIME: 2pm VENUE: room 514, Maths and Oceanography SPEAKER: Dr Abdel Babiker, MRC HIV Clinical Trials Centre, University College London Medical School TITLE: The analysis of multivariate failure time data with application to clinical trials in HIV infection ABSTRACT: Multiple time-to-event outcomes are measured in many clinical trials. However the analysis usually focuses on a single (possibly composite) endpoint so that standard methods of univariate survival data are used. The limitations of this approach will be highlighted and methods for the analysis of multivariate failure time data reviewed. These fall into three broad classes - marginal, conditional and frailty models. More recent developments in some of these models will be discussed and illustrated with data from clinical trials in HIV infection. ******************************************************************************** %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%