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Hi We are looking for some help in modelling adverse event data. We have data from a clinical trial in which subjects (80) were given a dose of drug twice a day for 6 days. A parallel dose-ranging design was used (including a placebo group): each subject only received one dose level. Subjects spontaneously reported a particular adverse event (that is they were not interrogated) and the time and duration of the event was recorded. Over 50% of the subjects reported no adverse events and the others reported between 1 and 8 events. There appears to be a dose-effect relationship in that most of the subjects reporting no event were on the lower doses. We would like to model the probability of adverse event as a function of dose and eventually drug blood concentration. We would appreciate any suggestions, particularly from people who have modelled analogous data. Thanking you in advance Leon Aarons __________________________________________________ Leon Aarons School of Pharmacy and Pharmaceutical Sciences University of Manchester Manchester, M13 9PL, U.K. tel +44-161-275-2357 fax +44-161-275-2396 email [log in to unmask] %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%