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Your explanation is quite correct. Binding of a number of things will increase anodic mobility - they include bilirubin, salicylates, and the most common cause in our experience is high dose penicillin and related antibiotics. Pam Riches On Thu, 9 Sep 1999 08:57:12 +0100 "R.W. Wulkan" <[log in to unmask]> wrote: > Dear collegue, > > Yesterday, I was called to inspect an unusual protein > electrophoresis pattern. One lane of the Paragon gel showed > an broad albumin band, "bearding" towards the anode, no > extra (prealbumin) band to be seen. The patient turned out > to have a chronic renal failure: kreat 480 umol/L, urea 63 > mmol/L, anion gap 24 mEq/L. Our present theory is that the > broadening is caused by association of albumin with charged > molecules, retained by severe renal failure. The patient > did not get albumin therapy. Is there anyone familiar with > this phenomenon? > > The only bearding band known to us thus far are the > Dubliners, so we propose the name albumin Dubliners. > > Best wishes > > Raymond Wulkan > Zuiderziekenhuis Rotterdam > The Netherlands ----------------------------------- pamela riches [log in to unmask] St. Georges Hospital Medical School Opinions expressed those of the author and not the institution %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%