Dear Mailbase members Thanks for the interest in my question and for all the contributions to the discussion. In conclusion I would summarise the points made as follows: 1. Under the circumstances the request for TFT's was appropriate. 2. Thyroid hormone replacement can be given whilst awaiting the results of TFT's without harming the patient. 3. Whether TFT's are measured immediately, the next day/working week depends on the department's equipment and the availability of trained staff. 4. Interpretation of the results is not straightforward in acutely ill patients. 5. A protocol for the authorisation of non standard out of hours requests should be in place. Regards John Tovey Nevill Hall Hospital %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%