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In message <[log in to unmask]>, ghlester <[log in to unmask]> writes >We have been working up Abbott AxSYM Troponin I assay for introduction into >routine service. Presently we do Vitros total CK with AxSYM CK-MB mass in >selected cases by special request. We have been doing TnI on these CK-MBs >in parallel. Findings reinforce the paper in Feb 99 Clinical Chemistry but >we came across this case which has puzzeled us. Does anyone have any >experience to throw light on the situation? > >A 93 year old lady admitted via A&E (ER for colleagues in US) with history >of "fall, collapsed, low temperatue ?cause". > >Admission: CK 1372 iu/L (Ref Range < 135) > CK-MB 131 ug/L ( < 7.0 ) > TnI 0.2 ug/L > >9 hours later: CK 794 > CK-MB 68.4 > TnI 0.2 > Trop T 0.02 ug/L ( < 0.10 ) >Non-specific ECG changes were noted. > > >35 hours later: CK 428 > CK-MB 22.9 > TnI 0.1 > >Do the AxSYM CK-MB or TnI assay suffer HMMA effects? Results of CK >isoenzymes by electrophoresis are awaited. > >Thanks > >Geoff Lester >Chemical Pathology Department >Frenchay Hospital >BRISTOL UK. >[log in to unmask] A HAMSA effect is documented for CK-MB. The cTnI results are consistent with the cTnT value. Tjhis is a non cardiac CK/CK-MB elevation -- Paul Collinson %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%