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In message <[log in to unmask]>, McNeely, Michael <[log in to unmask]> writes >We have a local "dispute" regarding the reporting of serum protein >electrophoretic patterns in which a monoclonal gammopathy has appeared. > >Both "camps" believe that reporting a quantitation of the monoclonal band is >appropriate. > >However, the difference lies in how the rest of the gamma globulin region should >be reported. > >1. One camp feels that the "gamma globulin" should be all the gamma globulin >(the sum of the monoclonal plus all the "normal" gamma globulin). >2. The other camp wishes to report the monoclonal and then "all the rest" of the >gamma globulin as a separate amount (total gamma minus the monoclonal). > >The arguement for option 2 is that it provides a better indication of >hypogammaglobulinemia or "nromal" gamma proteins. The counter arguement is that >the monoclonal measurement includes a portion of the "normal" gamma globulin >within it. > >Is there a guideline covering this? > >Michael McNeely MD FRCPC > > I don't knoew if there is a guideline: we use option 2. TIM -- Prof. Tim Reynolds, Professor of Chemical Pathology, Queen's Hospital, Burton-on-Trent, UK. %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%