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Re: Reply to abstract from APA Fibromyalgia, like many problems has components of emotional and somatic influences. Research performed by NIH has found certain serum abnormalities in patients with FM compared to controls. For example, low levels of seretonin, low levels of magnesium which is a necessary component for seretonin absorption, disturbed neuroendocrine functions including the production of GH, cytokines like interlukin-1, natural killer cells, abnormally low levels of norepinephrine, low levels of neuropeptide-Y, abnormal glucose metabolism, elevated levels of substance P in CSF, abnormal meletonin secretion, low levels of tryptophan, disturbed circadian rhythm, abnormal cortisol levels, pineal gland dysfunctions and thus pituitary problems, reduced levels of dopamine. Not every patient who has FM demonstrates all of these problems, but combinations of these result in severe neurologic, hormonal, physiologic, and yes emotional and psychological disorders. Karen Worden,MS,PT [log in to unmask] %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%