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Dr. M. Steiner wrote: > > Dear colleagues, > I recently came across the statement that adverse effects of heparin > include elevation of serum transaminase(s). As I have no first-hand > experience (I simply never looked into this phenomenon), I would > appreciate any comments on the follwong questions: > 1. Is this a common finding or is the evidence rather from case reports? > 2. Do ALAT and/or ASAT activites rise? > 3. Are there any ideas on an underlying mechanism? > 4. What is the natural course of the elevated enzyme activities after > cessation of heparin therapy? > 5. Do unfractionated and LMW heparins have the same potential to cause > increased transmaninase(s) activities? Is the effect dose-dependent? > > Thank you for your input. > > Dr. med. Michael Steiner > University of Rostock > Institute of Clinical Chemistry & Pathobiochemistry > Ernst-Heydemann-Str. 6 > 18057 Rostock > Germany > > fax: +49/381/494-7672 > email: [log in to unmask] ANSWER: There are at least 12 scientific reports concerning the increase of transaminases after heparin therapy.For details please see my web-site: http://home1.swipnet.se/~w-12360/ or http://www.pharmasoft.se/index2.html The 8th edition of the book "Drug effects in clinical chemistry" will be published in 1999. With kind regards Nils Tryding E-mail: [log in to unmask] Fax:+46 44 241260 Box 57,S-296 21 Åhus, Sweden %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%