Thanks to Robert Beetham for suggesting this pre-analytical enquiry. You are asked for advice by a Community Physician. His patient is a 52 year old lady with a Cushingoid pattern of obesity and hirsutism. Her current medication is 25 mg prednisolone for polymyalgia rheumatica, and a range of drugs for schizophrenia. How should she be investigated for Cushning's syndrome? Best wishes Gordon Challand %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%