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Dear colleagues I hope you all enjoyed your summer break. To restart the Cases for Comment, this one landed on my desk early in August. A 29 year old female patient, visiting her Community Physician. Clinical information is 'On methadone. Erratic periods. Polycycstic ovaries?' Serum FSH: <0.1 U/L (follicular phase 2 - 11) LH: 1.7 U/L (follicular phase 1 - 10) Prolactin: 3025 mU/L (80 - 530) Oestradiol: 13200 pmol/L (follicular phase 75 - 260) Comment (maximum 2 lines if possible please) and or other action directly to me please ([log in to unmask]), not to the mailbase. An assessed comment summary will be circulated as usual next week. Best wishes Gordon Challand %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%