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Dear colleagues, We have a problem with a patient who continues to be symptomatic despite the successful resection of an apparently non-secreting paraganglionoma. We have been unable to determine any elevated products which might explain the persistent of symptoms. The patient's main complaint is episodes of flushing. The Professor of Endocrinology has asked if we can arrange to measure adrenomedullin and CGRP (Calcitonin gene related peptide) as markers of possible peptide secretion from a further tumour she may be harbouring. Does anyone measure these products or know of a likely assay. Does anyone have experience of appropriate collection conditions ? Dr. T.A. Gray Department of Clinical Chemistry, Northern General Hospital, Sheffield. S5 7AU 0114 271 4309 %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%