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Jon, You wrote:- >(1) What happens to FSH and/or LH in normal "ovulating" women on Depo, and >(2) What happens to the postmenopausal FSH/LH levels while still on Depo ? According to Upjohn, the answers are:- 1. The tend to be low end of normal - this is some of the reason of course for the concerns about osteoporosis in long term users are oestrogen levels are thought to be lower. 2. The postmenopausal rise outweighs the lower effects of depo-provera & so they rise, although possibly later than they otherwise would Iain Dr I S Kewley GP in Ormskirk Lancashire Healthcare Sysop UK Professionals Forum CompuServe %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%