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Hello, I was recently troubleshooting this issue, and indeed this means that your pytorch version is too new for this model. As mentioned in Relion 4 GitHub page, (https://github.com/3dem/relion/tree/ver4.0) the classranker model was made with: Python 3.9.12 with Pytorch 1.10.0 and Numpy 1.20.0 So you can fix it as follows (using conda): conda create --name relion_torch python=3.9 conda activate relion_torch conda install pytorch=1.10.0 When you want to run the automatic class ranker in Relion 4 GUI you need to provide the path to the python from this newly created environment. Run the following commands: conda activate relion_torch which python Hope this helps! Best wishes, Vadim Kotov ######################################################################## To unsubscribe from the CCPEM list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCPEM&A=1 This message was issued to members of www.jiscmail.ac.uk/CCPEM, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/