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New issue alert         [log in to unmask]&cs_esp=campaigner&dfp_jnlmergecode=alcalc">       Volume 56 Issue 5   September 2021       Treatments for Alcohol Withdrawal and Alcohol Use Disorder       The Effectiveness of Non-Benzodiazepine, Non-Barbiturate Medications for Alcohol Withdrawal Syndrome: A Rapid Systematic Review     Abhishek Ghosh; Tathagata Mahintamani; Shinjini Choudhury; Nidhi Sharma ; Sauvik Das     Cognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis     Kahini Mehta; Ariel Hoadley; Lara A Ray; Brian D Kiluk ; Kathleen M Carroll ...     Use of Nalmefene in Routine Practice: Results from a French Prospective Cohort Study and a National Database Analysis     Henri-Jean Aubin; on behalf of the USE-PACT study group; Caroline Dureau-Pournin ; on behalf of the USE-PACT study group; Bruno Falissard ...   Short Summary: Two studies were used to evaluate how nalmefene is used in the management of alcohol dependence in France. After 1 year, new nalmefene users had substantially reduced alcohol consumption. Insurance data confirmed external validity of the population sample and the observation that patients often discontinue treatment over 1 year.     Safety and Persistence of Nalmefene Treatment for Alcohol Dependence. Results from Two Post-authorisation Safety Studies     Jonathan Chick; Frank Andersohn; Sylvie Guillo ; Kathrin Borchert; Massoud Toussi ...   Short Summary: Two studies were used to evaluate the safety and persistence of nalmefene in the routine management of alcohol dependence in Europe as part of the overall risk management plan. Although adverse events appeared more common in over 65-year olds, there were no major differences in safety outcomes between the total population, and those with psychiatric and somatic comorbidities or those with a history of seizures. Findings were in line with those from previous clinical studies. The differing rates of persistence beyond 1 year (49% in the prospective study and < 5% in the multi-database retrospective cohort study) likely reflect the different study methodologies and serve to highlight the relevance of follow-up support.     Efficacy of Self-Administered Intranasal Oxytocin on Alcohol Use and Craving After Detoxification in Patients With Alcohol Dependence. A Double-Blind Placebo-Controlled Trial     Katrine Melby; Rolf W Gråwe; Trond O Aamo ; Eva Skovlund; Olav Spigset   Short Summary: Intranasal oxytocin did not significantly reduce alcohol craving or relapse compared with placebo the first four weeks after detoxification in alcohol-dependent patients. The oxytocin treatment group did report a statistically significant decrease in self-reported nervousness.     [log in to unmask]&cs_esp=campaigner&dfp_jnlmergecode=alcalc">   A Longitudinal Mediation Model of Negative Emotionality, Coping Motives and Drinking Intensity Among Individuals Receiving Community Treatment for Alcohol Use Disorder     Victoria R Votaw; Elena R Stein; Katie Witkiewitz   Short Summary: To examine predictive validity of the Addictions Neuroclinical Assessment negative emotionality domain, we assessed longitudinal associations among this domain, coping motives and drinking intensity among treatment seekers who experienced a lapse to drinking. Negative emotionality was indirectly associated with drinking intensity following treatment initiation through coping motives for alcohol use.       Alcohol and Sex Differences       Sex Differences in Acute Alcohol Sensitivity of Naïve and Alcohol Dependent Central Amygdala GABA Synapses     Dean Kirson; Sophia Khom; Larry Rodriguez; Sarah A Wolfe ; Florence P Varodayan ...   Short Summary: Female central amygdala (CeA) GABAA receptor current kinetics are faster than males and depend on estrous cycle, with alcohol dependent animals having slower kinetics. Acute alcohol increases presynaptic GABA release in male CeA but has no effect in naïve female CeA. High concentrations of alcohol increase GABA release in dependent female CeA.     Alcohol Hangover Across the Lifespan: Impact Of Sex and Age     Joris C Verster; Noortje R Severeijns; Annabel S M Sips; Hama M Saeed ; Sarah Benson ...   Short Summary: This study shows that subjective intoxication, hangover severity and hangover frequency decline with age. The relationship between age and hangover severity is strongly mediated by subjective intoxication. An age-related decline in sensitivity to pain may in part explain the observed negative relationships.       Alcohol, Bariatric Surgery and Gut Microbiome       Differential Response in Ethanol Behaviors of Female Rats Given Various Weight Loss Surgeries     Elise R Orellana; Mary K Piscura; Nelli Horvath; Andras Hajnal   Short Summary: This study confirms, for the first time in female rats, that RYGB increases and SG decreases alcohol intake. An experimental surgery, combining RYGB and SG, confirmed that removal of the remnant stomach decreases ethanol drinking. These results point to ghrelin as a possible contributor to increased ethanol consumption following RYGB.     Changes in the Gut Microbiota Following Bariatric Surgery Are Associated with Increased Alcohol Intake in a Female Rat Model     Olivia A Martin; Silvia Grant-Beurmann; Elise R Orellana; Andras Hajnal ; Claire M Fraser   Short summary: The gut microbiota diversity and composition are altered in distinct ways after RYGB or VSG surgeries. We observed that a decrease in gut microbiota diversity is associated with EtOH intake after surgery and this may contribute to the increased incidence of AUD observed clinically in the bariatric surgery population.     [log in to unmask]&cs_esp=campaigner&dfp_jnlmergecode=alcalc">       Research on Alcohol Marketing       Understanding the Broader Impacts Of Alcohol Marketing: Time For a Research Agenda Which Includes Adults     Nathan Critchlow; Crawford Moodie     A Content Analysis and Population Exposure Estimate Of Guinness Branded Alcohol Marketing During the 2019 Guinness Six Nations     Alexander B Barker; Jaspreet Bal; Rachael L Murray       Lettters to the Editor       Minimizing Assessments of Alcohol Advertising in the Six Nations Rugby Championship     Frank Houghton     Response to Houghton’s Letter: ‘Minimizing Assessments of Alcohol Advertising in the Six Nations Rugby Championship’     Alexander B Barker; Jaspreet Bal; Rachael L Murray     Comment on ‘Does Advice Based on Biomarkers of Liver Injury or Non-Invasive Tests of Liver Fibrosis Impact High-Risk Drinking Behaviour: A Systematic Review and Meta-Analysis’     Alexander Smith; Kate Glyn-Owen,; Ryan Buchanan     Reply to Smith et al. Regarding ‘Does Advice Based on Biomarkers of Liver Injury or Non-Invasive Tests of Liver Fibrosis Impact High-Risk Drinking Behaviour: A Systematic Review with Meta-Analysis’     Mohsan Subhani; Holly Knight; Stephen Ryder; Joanne R Morling     L-cysteine and the Treatment of Alcohol Hangover: A Commentary on Eriksson et al. (2020)     Sarah Benson; Andrew Scholey; Joris C Verster     Response to Letter by Benson et al. on ‘Hangover and the Effects of L-Cysteine’     C J Peter Eriksson; Markus Metsälä; Tommi Möykkynen; Heikki Mäkisalo ; Olli Kärkkäinen ...       Corrigenda       Erratum to: Cognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis     Kahini Mehta; Ariel Hoadley; Lara A Ray; Brian D Kiluk ; Kathleen M Carroll ...     Corrigendum to: Alcohol Hangover Across the Lifespan: Impact Of Sex and Age     Joris C Verster; Noortje R Severeijns; Annabel S M Sips; Hama M Saeed ; Sarah Benson ...     Corrigendum to: Use of Nalmefene in Routine Practice: Results from a French Prospective Cohort Study and a National Database Analysis     Henri-Jean Aubin; on behalf of the USE-PACT study group; Caroline Dureau-Pournin ; on behalf of the USE-PACT study group; Bruno Falissard ...     Corrigendum to: Ashamed and Alone—Risk Factors for Alcohol Craving Among Depressed Emerging Adults     Elena Bilevicius; Courtney C Clark; Edward A Johnson; Matthew T Keough