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Thanks for the quick reply! That's what I assumed, however, does this denote a statistically significant positive relationship or negative and the effect of the covariate on the FA. Would I need to extract the FA from those regions and do further statistical analysis to determine the exact relationship? Thanks! Erin ######################################################################## To unsubscribe from the FSL list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=FSL&A=1