Dear all,
I have a rather complex design and wanted to know whether my reasoning and design are right.
DTI data of a patient group (25 subjects), before and after surgery (removal of tumour). I also obtained cognitive test scores from pre- and post surgery. They will be inserted separately and also together.
Question: Relation between pre- and post surgical changes in FA and cognitive test scores
Followed this link: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/GLM#Single-Group_Paired_Difference_.28Paired_T-Test.29
I explicitly set the exchangability group values for randomise.
5 example patients:
Number of EVs: 8 ( last two are cognitive test scores)
Number of additional, voxel-dependent EVs: 0
Score 1: a transformed index score
Score 2: amount of omitted targets.
Group EV1 EV2 EV3 EV4 EV5 EV6 score1 score2
1 1 1 0 0 0 0 -0.23 0
2 1 0 1 0 0 0 0.37 7
3 1 0 0 1 0 0 0.21 2
4 1 0 0 0 1 0 -0.01 0
5 1 0 0 0 0 1 -0.03 10
1 -1 1 0 0 0 0 0.27 4
2 -1 0 1 0 0 0 0.02 7
3 -1 0 0 1 0 0 -0.36 0
4 -1 0 0 0 1 0 -0.28 2
5 -1 0 0 0 0 1 0.02 9
Contrasts: 3
F-tests: 0
Title EV1 EV2 EV3 EV4 EV5 EV6 score1 score2
C1 Pre-post1 1 0 0 0 0 0 1 0
C2 Pre-post2 1 0 0 0 0 0 0 1
C2 Pre-post1&2 1 0 0 0 0 0 1 1
Then run:
randomise -i PairedT4D -o PairedT -d design.mat -t design.con -e design.grp -m mask -n 10000 -T -x
Am I on the right path with regard to my reasoning and design?
Best wishes,
Joeri
########################################################################
To unsubscribe from the FSL list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=FSL&A=1
