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Good thought Mohmed In the Roche assay biotin interference results in raised fT4 and reduced TSH, hence mimicking hyperthyroidism. Not sure about other manufacturer’s methods. Lesley From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Mohmed Ashmaig Sent: 07 November 2019 12:54 To: [log in to unmask] Subject: [EXTERNAL] Re: Thyroid Hormone Interference Studies ________________________________ WARNING: This message originated from an external source. Please exercise caution when opening any attachments or clicking on links. ________________________________ Hello Gina, Also please pay attention to the biotin interference, if your method using biotin and patient taking biotin (for nail and hair beauty) that is one of the common cause of erroneous results, I have seen that as a common issue here in US, Biotin supplement also comes as one of the ingredients of some supplements, Just a possible thought to consider Thanks Mohmed On Thursday, 7 November 2019, 05:21:23 GMT-6, FREDERICK, Gina (UNIVERSITY HOSPITALS OF DERBY AND BURTON NHS FOUNDATION TRUST) <[log in to unmask]> wrote: Dear Mailbase Hoping for some clarification on the usual practice of UK Labs when investigating possible interference in thyroid hormone assays. Currently, if our Endocrinologists suspect interference in TSH/fT4/fT3, we perform TFTs pre- and post-blocking tube, send for assay on an alternative platform, and also sometimes send to QEH in Birmingham for the full thyroid antibody interference screen. But we don't always have a consistent approach. What does everyone else do? Do you just do blocking tubes, or assay on alternative platform, or both? When would you send for the full interference screen? Is there any best practice guidance out there? Any advice would be much appreciated! Thanks in advance. 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