Hi Neda, 

fslvbm isn’t setup to work with data like in this manner. Currently the fslvbm pipeline wants equal numbers of patients and control participants so that both the study template and the stats aren’t systematically skewed towards a particular group. 

You could take a look at the fslvbm scripts and reproduce the necessary preprocessing steps at the single subject level. 

Then, you could use a one-sample t-test in randomise on the difference GM images of every control minus patient pair in standard space (so after registration). 

This is definitely going to be a bit of a custom vbm analysis though. 

https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Randomise/UserGuide#One-Sample_T-test

Cheers,

Taylor Hanayik


Taylor Hanayik PhD

Analysis Research Software Engineer
FMRIB, John Radcliffe Hospital
University of Oxford
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On 28 Sep 2019, at 10:08, Neda Mohammadi <[log in to unmask]> wrote:

Hello everyone

I have a question about fslvbm. I want to compare a patient with a group of normal subjects, does anybody know how to do vbm analysis at the single subject level?

Thanks 

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