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Senior Bioinformatics Scientist at C4X Discovery Salary: £35,000.00 minimum + extensive benefits Hours: 40hrs per week. Mon-Fri (core hours 10am-4pm) Location: London Office Reporting To: VP, Novel Target Biology & Genomics Grade: 5 Grade Responsibilities: - Provide leadership or management to key projects within area of expertise - Apply knowledge in area of specialism to influence project progression - Make independent decisions that determine the successful delivery of project outcomes - Proactively troubleshoot to identify solutions to problems in own area of work - Contribute ideas to improve working practices C4X Discovery is currently looking to extend its drug discovery team with an experienced, highly motivated Senior Bioinformatician, with human genome experience. Background: C4X Discovery is a drug discovery company based in Manchester and London: it successfully concluded its first licensing deal during 2018. The company is based around two key cutting-edge technologies: Conformetrix analysis of small molecule shape in solution; and Taxonomy3 analysis of human genetic datasets. Taxonomy3 is a unique method for analysing human genetic data developed by C4X and based on application of novel mathematics. The method extracts additional genetic insights from the datasets, and these insights are used to identify drug targets for progression within C4X Discovery. We are now looking for a bioinformatician to join our discovery genetics function to expedite this transition of genetic insights into new drug targets. This individual will make a significant impact in a number of areas: 1. Analysis of the results of Taxonomy3 requires access to, and assimilation of, a broad range of algorithms and databases. Ensuring that the most appropriate approach is identified to progress our projects and applying these methods to our datasets are important aspects of the role. 2. The output of the Taxonomy3 analysis comprises a list of genes of interest, plus gene-gene interactions. This unique output requires cutting-edge bioinformatic assessment to identify key pathways, networks etc.*en route* to identifying novel drug targets. 3. The Taxonomy3 method is already yielding valuable results that have been translated into drug discovery programmes. In addition, we are looking to develop the methodology further to enhance the outputs from the analyses. Significant bioinformatics input will also be needed as a key part of these technology developments. 4. An additional important part of the role is to keep abreast of developments in the bioinformatics field and incorporate them into C4X’s target identification and drug discovery pipelines. This is an exciting opportunity for a creative bioinformatician to join an innovative discovery genetics team and make a significant impact in drug discovery. Role Responsibilities: - Identifying and applying appropriate bioinformatics methods to our Taxonomy3 analysis pipeline to expedite drug target identification - Using bioinformatics expertise to support: effective management of genetic datasets; development and maintenance of the Taxonomy3 Database; development of the NGS platform - Keeping up with bioinformatics progress – databases, tools, methodology – and drive the development of new in-house tools based on these - Maintaining and improving the Taxonomy3 support and visualisation functions (e.g. SNP-to-gene mapping, bash, Rshiny) - Taking initiative in progressing R&D of the Taxonomy3 method Education, Experience & Skills Required: - PhD in Genetics/Biology/Statistics/Biostatistics/Bioengineering, or equivalent experience: postdoctoral experience in drug discovery is advantageous - Experience of the application of genome technologies and bioinformatics in the context of human genomics and genetics - Unix/Linux environment expertise, plus advanced programming skills in Perl/Python and shell scripting or other equivalent languages - Knowledge of and experience with the use of statistical methods and programming languages such as R and experience with query languages (e.g. mySQL) - Familiarity with public biomedical information resources such as genome browsers, data repositories and annotation databases - Good presentation skills/Team player/Eager to learn and put together novel methodological pipelines - Excellent team working, organisational and communication skills and attention to detail. - Fluent written and spoken English - Knowledge of NGS pipelines and analysis methods would be advantageous C4X Discovery offers a broad selection of health benefits, share options, a generous pension scheme and an annual, discretionary bonus scheme. Send CV & cover letter to [log in to unmask] For a full job description and person specification, visit www.c4xdiscovery.com where you will also find more information on the C4XD Drug Discovery Engine business model and details on how your personal data will be handled throughout the recruitment process. -- *Kind Regards* Zhana Kuncheva, PhD Target Discovery Genetics Project Leader C4X Discovery Ltd [log in to unmask] +44 (0)20 3198 0027 *www.c4xdiscovery.com <http://www.c4xdiscovery.com>* -- Confidentiality Notice: This email and any attachments may be confidential and protected by legal privilege. If you are not the intended recipient, be aware that any disclosure, copying, distribution or use of the e-mail or any attachment is prohibited. If you have received this email in error, please notify us immediately by replying to the sender and then delete this copy and the reply from your system. Thank you for your cooperation. 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