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Many of the laboratories in MetBioNet (UK metabolic network of laboratories) quantitate both plasma & urine citrulline as part of the amino acid profile. These are available as you will be aware in the metabolic laboratory in Bristol. When reporting amino acid profiles overall assessment of the whole profile in relation to the clinical details supplied will offer diagnostic/clinically relevant information. In cases of known intestinal failure where arginine/ornithine/citrulline concentrations are particularly relevant these should be considered as part of the clinical interpretation. As specific markers for detecting intestinal failure the sensitivity of using these amino acids is to my knowledge uncertain.

Best wishes

Simon

Dr S Olpin MSc PhD CSci EuSpLM FRCPath

Head of Department & Director of Regional Newborn Screening

Consultant Clinical Scientist in Inherited Metabolic Disease

Sheffield Children's Hospital

Sheffield S10 2TH

0114 2717267

Please note that the Head of Department & Director of Regional Newborn Screening is a job share with Camilla Scott [log in to unmask]

I work 4 days a week usually not Thurdays.

[log in to unmask]">>>> Frances Palmer <[log in to unmask]> 08/03/2019 14:33 >>>

Dear Mailbase,

Does anyone measure Citrulline (either alone or part of a more detailed amino acid profile) in their laboratory for use as a marker in intestinal failure/intestinal absorption?

Many thanks

Dr Frances Palmer

Chemical Pathology Registrar

Southmead Hospital

Bristol

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