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Many of the laboratories in MetBioNet (UK metabolic network of laboratories) quantitate both plasma & urine citrulline as part of the amino acid profile. These are available as you will be aware in the metabolic laboratory in Bristol. When reporting amino acid profiles overall assessment of the whole profile in relation to the clinical details supplied will offer diagnostic/clinically relevant information. In cases of known intestinal failure where arginine/ornithine/citrulline concentrations are particularly relevant these should be considered as part of the clinical interpretation. As specific markers for detecting intestinal failure the sensitivity of using these amino acids is to my knowledge uncertain. Best wishes Simon Dr S Olpin MSc PhD CSci EuSpLM FRCPath Head of Department & Director of Regional Newborn Screening Consultant Clinical Scientist in Inherited Metabolic Disease Sheffield Children's Hospital Sheffield S10 2TH 0114 2717267 Please note that the Head of Department & Director of Regional Newborn Screening is a job share with Camilla Scott [log in to unmask] I work 4 days a week usually not Thurdays. >>> Frances Palmer <[log in to unmask]> 08/03/2019 14:33 >>> Dear Mailbase, Does anyone measure Citrulline (either alone or part of a more detailed amino acid profile) in their laboratory for use as a marker in intestinal failure/intestinal absorption? Many thanks Dr Frances Palmer Chemical Pathology Registrar Southmead Hospital Bristol DISCLAIMER: The information in this message is confidential and may be legally privileged. It is intended solely for the addressee. Access to this message by anyone else is unauthorised. If you are not the intended recipient, any disclosure, copying, or distribution of the message, or any action or omission taken by you in reliance on it, is prohibited and may be unlawful. Please immediately contact the sender if you have received this message in error. Thank you. ﾭﾭ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual who posts and they are solely responsible for all message content. The ACB does not monitor posts. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ **************************************************************************************************** Sheffield Children's NHS Foundation Trust Western Bank Sheffield. S10 2TH www: http://www.sheffieldchildrens.nhs.uk The Children's Hospital Charity http://www.tchc.org.uk/ Donate here http://www.justgiving.com/tchc/donate DISCLAIMER: This "e-mail" (which also means any attachments) may contain personal and/or sensitive confidential or privileged material. It is intended only for the addressee. If you have received this e-mail in error, please return it to the sender and delete the material from any computer system/backup. The Data Protection Officer for the Trust is Russell Banks (Head of IM&T) and can be contacted via the Trust switchboard 0114 2717000 or via [log in to unmask] Unless explicitly stated to the contrary, any views or opinions expressed are personal to the author and do not represent the views, opinions or policies of Sheffield Children's NHS Foundation Trust. This e-mail and its contents may be subject to public disclosure under the Freedom of Information Act 2000. Unless the information is legally exempt from disclosure, the confidentiality of this e-mail and your reply cannot be guaranteed. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual who posts and they are solely responsible for all message content. The ACB does not monitor posts. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/