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Hi Jesper,

Useful to know about the diminishing returns of the extra b0s; I've
adjusted my inputs accordingly to avoid this taking an extraordinarily long
time (got about 300 inputs!).

Thanks very much for your reply,
Iain

On Wed, 20 Feb 2019 at 16:26, Jesper Andersson <
[log in to unmask]> wrote:

> Dear Iain,
>
> >
> > I'm processing some DTI information and using topup in the preprocessing
> to estimate the fieldmaps for geometric distortion correction. My question
> is that it's been running for > 2 hours now on one dataset and it still
> hasn't exited. I've used topup before on the same computer / FSL
> installation and don't remember it taking anything like this long (though
> admittedly that was on a dataset with only 2 b0s of opposite blips;
> currently I've got 8 b0s being processed). The logfile hasn't got anything
> that looks like an error in it, and seems to have stalled at the current
> point (it's been sitting at the same stage for at least an hour when I
> first checked it). I'll paste the log file into the bottom of this email
> for reference.
> >
> > Is it normal for it to take this long perhaps due to the number of b0
> images? Or does it sound like it's hit a snag?
> >
> > The topup data is 8 b0 images, the first 5 are A >> P (image appears
> displaced "downwards"), and the last 3 are P >> A (displaced "upwards"). I
> got the total readout time from the .json file generated in DICOM
> conversion using dcm2niix. I'm 99% certain I've set up the acquisition
> parameters correctly:
>
> the execution time scales pretty much linearly with the number of volumes
> you have in your --imain file. My advice is to use only a single pair since
> one sees very little, if any, improvement of results by using more than
> that. We still recommend acquiring more than one (3-5) b0, but that is to
> make sure that you have at least one b0 for each direction that is not
> damaged by intra-volume movement.
>
> Jesper
>
> >
> > 0 -1 0 0.0690115 (x5)
> > 0 1 0 0.0690115 (x3)
> >
> > Thanks in advance for any advice,
> > Iain
> >
> >
> > #     name of 4D file with images
> > --imain=topup_b0s.nii.gz
> > # name of text file with PE directions/times
> > --datain=/mnt/hgfs/SHARED_FILES/Biobank/topup_acq_pars.txt
> > #     base-name of output files (spline coefficients (Hz) and movement
> parameters)
> > --out=1042018_topped_up
> > #     name of image file with field (Hz)
> > --fout=field
> > #     name of 4D image file with unwarped images
> > --iout=unwarped_images
> > # (approximate) resolution (in mm) of warp basis for the different
> sub-sampling levels, default 10
> > --warpres=20,16,14,12,10,6,4,4,4
> > # sub-sampling scheme, default 1
> > --subsamp=2,2,2,2,2,1,1,1,1
> > #     FWHM (in mm) of gaussian smoothing kernel, default 8
> > --fwhm=8,6,4,3,3,2,1,0,0
> > #     Max # of non-linear iterations, default 5
> > --miter=5,5,5,5,5,10,10,20,20
> > # Weight of regularisation, default depending on --ssqlambda and
> --regmod switches. See user documetation.
> > --lambda=0.005,0.001,0.0001,1.5e-05,5e-06,5e-07,5e-08,5e-10,1e-11
> > # If set (=1), lambda is weighted by current ssq, default 1
> > --ssqlambda=1
> > # Estimate movements if set, default 1 (true)
> > --estmov=1,1,1,1,1,0,0,0,0
> > # Minimisation method 0=Levenberg-Marquardt, 1=Scaled Conjugate
> Gradient, default 0 (LM)
> > --minmet=0,0,0,0,0,1,1,1,1
> > # Model for regularisation of warp-field [membrane_energy
> bending_energy], default bending_energy
> > --regmod=bending_energy
> > # Order of spline, 2->Qadratic spline, 3->Cubic spline. Default=3
> > --splineorder=3
> > # Precision for representing Hessian, double or float. Default double
> > --numprec=double
> > # Image interpolation model, linear or spline. Default spline
> > --interp=spline
> > #     If set (=1), the images are individually scaled to a common mean,
> default 0 (false)
> > --scale=1
> > #     If set (=1), the calculations are done in a different grid,
> default 1 (true)
> > --regrid=1
> >
> > ########################################################################
> >
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-- 
Dr Iain Croall, PhD
Postdoctoral Researcher
University of Sheffield
Dept. Infection, Immunity and Cardiovascular Disease
Academic Unit of Radiology
email: [log in to unmask]
phone: 0114 2159151

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