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Applications are invited for a PhD studentship starting from September 2019 in Dr. Arianna Fornili’s group at Queen Mary University of London and in collaboration with Dr. Julien Ochala at King’s College London. The aim of the project is to design and test small molecules that can either inhibit or activate cardiac myosin, a key component of the molecular machinery involved in heart contraction. A combined computational/experimental approach will be used, which will involve the use of molecular dynamics, molecular docking, virtual screening and in vitro biophysical techniques. Applications are welcome from outstanding students with, or expecting to obtain, a first or upper-second class honours degree in Chemistry, Pharmaceutical Chemistry, Biochemistry, Physics, Biophysics or related disciplines. A masters degree is desirable. Previous experience in molecular modelling/simulation is essential, previous experience in computer programming and/or experimental biophysical techniques is a plus. The studentship is funded by EPRSC and will cover tuition fees and an annual tax-free maintenance allowance at the Research Council rate (£16,777 in 2018/19) for 3.5 years. UK students, and EU students who have been ordinarily resident in the UK for at least 3 years are normally eligible for full EPSRC funding. For more information: https://www.qmul.ac.uk/sbcs/postgraduate/phd-programmes/projects/display-title-649759-en.html https://www.findaphd.com/phds/project/targeting-myosin-for-heart-disease-a-structure-based-approach-to-design-conformation-selective-modulators/?p105203 Before submitting a formal application online, please contact Dr. Fornili ([log in to unmask]<mailto:[log in to unmask]>) and include your CV, your academic transcripts, a cover letter explaining eligibility and interest in the project and the contact details of two academic referees. The deadline for formal applications is on the 31st of January 2019. Dr. Arianna Fornili Lecturer in Computational Organic Chemistry School of Biological and Chemical Sciences Joseph Priestley Building (room G.04) Queen Mary, University of London Mile End Road E1 4NS London UK email: [log in to unmask]<mailto:[log in to unmask]> Tel: +44 (0) 207 882 8446 website: https://afornililab.wordpress.com ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1