Thanks for your reply. We have done the unwrapping of the phase image before scaling. Please see attached figure. The images look fine. Still not sure what cause the over-correction of the FUGUE.

I am afraid I don’t think those images look fine. I don’t know what is going on, but the large off-resonance field towards the back of the brain does not look right. Also, it clearly looks like there is a wrap remaining, though it also looks like you can actually make a path from one side of the wrap to the other without passing another wrap. I have never seen anything like it, so cannot really say how this might have happened.

Jesper

Any thoughts?

Thank you, 

Ye

<FUGUE.jpg>

On Thu, Oct 25, 2018 at 1:58 AM Pablo Velasco <[log in to unmask]> wrote:

Hi Ye,

Have you tried unwrapping the phase difference image (before scaling it by the echo time difference)?

If that doesn't work, take a look at the unwrapping of the phase images, before taking the difference, and see if there are any phase wraps left uncorrected.

Best,

-Pablo

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Ye Tian, MD

PhD candidate

Melbourne Neuropsychiatry Centre

University of Melbourne, Australia

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