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Hi Rosalia, You should go with the first option - run melodic on all of your data. The resulting ICs will represent a sort of average between the two time points, that you can then use as a basis for comparing them. Cheers, Paul On 12/11/2018, Rosalia Dacosta Aguayo <[log in to unmask]> wrote: > Sorry for the double posting but I have been looking at the FSL mailing > list forum and in one of the mails it appears: subtraction of image post_IC > of interest - post_IC interest in order to get the image with which run the > 2*2 Repeated ANOVA. > > Could any one of you clarify me which would be the best approximation to > compare IC from a sample of two groups (control and experimental) which > have been assessed in two different time points? > > 1. Should I run Melodic for the whole sample pre and post to calculate just > one 4D file of IC? > 2 Should I run Melodic twice, one for T1 and another for T2, and, if yes, > who should I conduct the analysis? > > Best regards, > Rosalia > > On Mon, Nov 12, 2018 at 12:37 PM Rosalia Dacosta Aguayo > <[log in to unmask]> > wrote: > >> Dear FSL' experts, >> >> I am running Melodic with a fMRI-task in two groups (control and >> experimental) assessed in two different times (pre and post). The >> experimental group underwent cognitive rehabilitation and I want to >> compare >> them across the time. >> >> The doubt I have is that with dual_regression, in my design, I will only >> have an input (a component/group of components) to compare. I am a bit >> confused because I thought that I should run melodic for time 1 and >> melodic >> for time2 and then compare the output components. However, looking at >> this, >> I think that I should include pre and post together and compare the >> generated group of components, Melodic_IC.nii.gz, the result of IC from >> preprocessed pre and post participants, is that correct? I do not see it >> clear, as we are mixing components from two different times. >> Any clarification would be appreciated. >> >> Yours sincerely, >> Rosalia >> > > ######################################################################## > > To unsubscribe from the FSL list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=FSL&A=1 > ######################################################################## To unsubscribe from the FSL list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=FSL&A=1