Dear ccp4 community,
I have recently been working
with a structure that has an Asparagine that makes a planar stacking connection with a Tryptophan ring (pep_ASN-TRP_v2.png),
that seem to be a true pi-stacking interaction and I'd
like to find more examples of this.
I've found a few other examples in the literature but they are mostly amide hydrogen-pi interactions (4PTI_ASN-TYR_v2.png and 1N4W_ASN-FAD_v2.png), which can be seen by the way the Asn is dipping down into the pi-cloud. One potential exception is of a DNA-binding protein where the orientation is more planar (3HXQ_GLN-DNA_v2.png).
So, I'm
looking for examples of Asparagine or Glutamine pi-stacking and am sure there are more of them out there and would greatly appreciate any examples.
best regards
Michael
Michael Jarva, PhD
ACRF Chemical Biology Division
The Walter and Eliza Hall Institute of Medical Research
1G Royal Parade
Parkville Victoria 3052
Australia
Phone: +61 3 9345 2493
Email: [log in to unmask] | Web: http://www.wehi.edu.au/
The ACRF Chemical Biology Division is supported by the
Australian Cancer Research Foundation
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