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Hi Liam,

That's right. The answers have changed. That's why often it is worth
answering again a similar question, instead simply pointing to old answers
from a couple of years ago.

Specifically on this topic, three changes over time are worth commenting on:

1) There used to be a consensus that between-subject effects was not
possible using the simple GLM in repeated measures design. This changed
when it became clear that a model with all the within-subject effects in
the design could be constructed, leaving all the between subject effects of
no interest (and not otherwise explained by nuisance variables) in the
residuals, which then have the correct degrees of freedom, leading to
accurate inferences. This changed responses given for these cases.

2) Also for repeated measures designs, given that not all observations are
exchangeable, this used to be a no-no for permutation tests. However, with
the implementation of exchangeability blocks in randomise, this became
feasible.

3) The very idea of exchangeability blocks was later extended to
accommodate multiple levels, such that designs that involve interactions of
within and between-subject effects can now be analysed. This presently is
only available in PALM, but may become available in randomise too
eventually.

There are more things coming and some answers will change again in the
future...

All the best!

Anderson


On Fri, 12 Oct 2018 at 05:42, Nestor, Liam J <[log in to unmask]>
wrote:

> Tony
>
> It seems that these models are constantly changing - there are different
> ones proposed throughout the forum over the years - they can't all be
> correct? This model was described this year while mine was in 2015. How do
> you know any of them are correct - really? You are now having to try and
> guess which parts of the model are computing the different effects. Perhaps
> try implementing a 2x2 on your pre/post food addicted/non-food addicted
> data first? If you find clusters, then extract signal change and run the
> same model in SPSS to see if you see the same effects?
>
> Liam.
>
>
>
> Dr. Liam Nestor,
> Neuropsychopharmacology Unit,
> Imperial College London
>
>
> -------- Original message --------
> From: Tony Goldstone <[log in to unmask]>
> Date: 11/10/2018 20:34 (GMT+00:00)
> To: [log in to unmask]
> Subject: Re: [FSL] GLM for 3 (between subjects) x 2 (within subjects)
> repeated measures ANOVA
>
> or is the overall effect of drug (independent of group) better modelled by
> an F2 for C1-3 (rather than a C7 with 0.333 0.333 0.333 for EV1-3)?
> Tony
>
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