The Francis Crick Institute, London

 

The Francis Crick Institute seeks to recruit a Cryo-electron Microscopy (cryo-EM) Scientist to support single-particle and tomography projects.

 

The research scientist will be appointed to the Structural Biology Science Technology Platform (SB STP), which supports the Crick in the areas of protein science (expression and purification), biophysics, X-ray crystallography, cryo-EM and related areas.

 

There are excellent opportunities for career advancement.

 

The Crick has a state-of-the-art facility for cryo-electron microscopy and computation and the post will consolidate excellence in these areas. The STP currently houses two Titan Krios 300kV microscopes each equipped with a Volta phase plate and Falcon III detector (one has an additional Gatan energy filter and K2 detector) and these are complemented by a Talos Arctica 200kV microscope and a 120kV Spirit TEM screening microscope.

 

There are excellent facilities for computing and expertise in experimental and computational aspects of cryo-EM being developed through the structural biology platform with support from the Crick Scientific Computing STP.

 

Closing date is October 15, 2018

 

Details may be found here:

https://jobs.crick.ac.uk/pls/corehrrecruit//erq_jobspec_version_4.display_form?p_company=1&p_internal_external=E&p_display_in_irish=N&p_applicant_no=&p_recruitment_id=008364&p_process_type=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y

KEY RESPONSIBILITIES

 

These include but not limited to;

• Support a range of cryo-EM research activities through interaction with Crick scientists including cryo-EM scientists and other structural biologists interested in cryo-EM.
• Contribute to management and maintenance of high-end cryo-electron microscopes
• Support experimental design including sample preparation and imaging of biological specimens.
• Provide expertise and support in computational image analysis.
• Provide training in both experimental and computational aspects of cryo-EM.

 

 

ABOUT US

 

The Francis Crick Institute (the Crick) is a partnership between the Medical Research Council (MRC), Cancer Research UK (CRUK), the Wellcome Trust, University College London (UCL), Imperial College London and King’s College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.

 

 

KEY EXPERIENCE AND COMPETENCIES

 

The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:

 

Essential

• A higher degree in biological, physical, or engineering sciences.
• Research experience and expertise in electron microscopy.
• Specialist knowledge of cryo-electron microscope operation and high-resolution data collection.
• Proven track record in three-dimensional electron microscopy.
• Excellent communication skills within a research environment, building highly effective working relationships with scientists and support staff.
• Plan time efficiently and be able to work both independently and in a team setting.

Desirable

• PhD in Structural Biology or related areas.
• Experience in data analysis single particle images and/or tomography data.
• Experience with field emission gun microscopes and direct electron detectors.
• Postdoctoral experience in conducting cutting-edge research in cryo-EM.
• Authorship in peer-reviewed publications in internationally recognized scientific journals.
• Specialist knowledge of cryo-EM reconstruction software.
• Knowledge of scientific computing including Unix shell scripting, Matlab, Python, programming languages.
• Flexible working practice.

 

For any questions, please contact us on [log in to unmask], Phil Walker (Head, SB STP; [log in to unmask]) or Peter Rosenthal (Senior Group Leader; [log in to unmask] )