Hi,

As far as I know, the salience network is part of most templates. You would typically want to include *all* networks in the dual regression though, because the multiple regression takes into account the other networks when estimating the subject-specific maps for the salience network. So even if you’re only interested in the salience network, I would recommend including all maps in the dual regression. You can either switch off permutation testing (stage 3) and manually run it only for the salience network, or you can delete stage 3 results for all other networks post hoc.

Cheers,

Janine

On 7 Sep 2018, at 15:11, Jose Pineda <[log in to unmask]> wrote:

Thank you Janine,

Are you aware of an available template that could be used to study the salience network as a single IC?

Thanks!

José

El vie., 7 sept. 2018 a las 8:36, Janine Bijsterbosch (<[log in to unmask]>) escribió:

Hi,

You should definitely *not* create group IC maps based on the healthy controls only. This will introduce a statistical bias into your analysis because your maps are driven by just one of your subject groups.

The best option is probably to include all 45 scans and obtain group IC maps from this. Taking this approach has the advantage of finding study-specific noise maps, and including these in subsequent dual regression analysis provides second-level cleanup. It is also a good option to use templates from existing datasets. It isn’t really the case that one set of templates is more suitable than another, so you can pick for example based on how well the templates match the existing literature in your field.

Best wishes,

Janine

On 6 Sep 2018, at 18:10, Jose Pineda <[log in to unmask]> wrote:

Hello,

I'm running a dual regression analysis on a local dataset with Ncontrol 15, Npatients 15, being the patients scanned under two conditions. Regarding the creation of IC group networks I see that there are two options, either to include all scans (N45), or just the healthy controls group, correct?.
Could I also use network templates from other datasets as the one published in Smith et al. PNAS 2009? If yes, which templates will be the more suitable for this matter and what options do I have?

Thanks
José

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Dr Janine Bijsterbosch
Postdoctoral Researcher
FMRIB Centre, University of Oxford
John Radcliffe Hospital
Oxford, United Kingdom
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José Angel Pineda-Pardo

Postdoctoral Researcher
hmCINAC - HM Puerta del Sur

Av Carlos V 70, Móstoles, Spain

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Dr Janine Bijsterbosch
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FMRIB Centre, University of Oxford
John Radcliffe Hospital
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