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Augustin, I worry that your argument is a non-sequitur. The fact that you cannot be killed by a placebo does not imply that they are ineffective. There are many effective drugs that don’t kill you from overdose. The placebo effect is neither as weak as sceptics claim, nor as strong as proponents assert<https://www.huffingtonpost.co.uk/jeremy-howick/placebo-effects_b_10906256.html?guccounter=1&guce_referrer_us=aHR0cDovL3d3dy5qZXJlbXlob3dpY2suY29tL2xhdGVzdC11cGRhdGVzL3doYXRzLXRydXRoLXBsYWNlYm8tZWZmZWN0cy8&guce_referrer_cs=GzjrxYEzagWVBKpXmq6pBw>. Like with many things, the truth lies somewhere in the middle. Best wishes, Jeremy My latest book here: Doctor You <https://www.amazon.co.uk/Doctor-You-Revealing-science-self-healing/dp/1473654203> T: +44 (0)1865 289 258 E: [log in to unmask] http://www.phc.ox.ac.uk/team/jeremy-howick Nuffield Department of Primary Care Health Sciences, University of Oxford Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG On 04/09/2018 16:50, "Evidence based health (EBH) on behalf of Agustín Gómez de la Cámara" <[log in to unmask]<mailto:[log in to unmask]> on behalf of [log in to unmask]<mailto:[log in to unmask]>> wrote: The question is whether the placebo really exists (main premise). I do not know anyone who could have committed suicide because of a massive placebo intake. Agustín Agustín Gómez MD, MPH, PhD. Biomedical Resarch Institute. Hosptial 12 de Octubre. Madrid. Spain -----Mensaje original----- De: Evidence based health (EBH) <[log in to unmask]<mailto:[log in to unmask]>> En nombre de Max Solano Enviado el: martes, 04 de septiembre de 2018 17:14 Para: [log in to unmask]<mailto:[log in to unmask]> Asunto: Natural history versus Placebo From a Wall Street Journal interview (25-26 August) with Dr. Scott Gottlieb, U.S. F.D.A. Commissioner ….“You don’t have the traditional three phases of clinical trials,” he explains, “but you have one continuous trial,” enrolling more people as you go. More broadly, the placebo trial, in which some patients receive a sugar pill or solution, is ill-suited to many situations. Sometimes there are too few patients. Sometimes there are ethical problems with putting patients through a painful placebo regimen. An alternative is to compare the drug against “natural history”—data about how patients usually fare over time without treatment. In many cases, “the decline is predictable,” Dr. Gottlieb says. “If we could develop good natural-history models in these diseases, then we wouldn’t have to rely as much on placebo.” Comments ######################################################################## To unsubscribe from the EVIDENCE-BASED-HEALTH list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=EVIDENCE-BASED-HEALTH&A=1 ######################################################################## To unsubscribe from the EVIDENCE-BASED-HEALTH list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=EVIDENCE-BASED-HEALTH&A=1 ######################################################################## To unsubscribe from the EVIDENCE-BASED-HEALTH list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=EVIDENCE-BASED-HEALTH&A=1