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The default spatial normalisation in SPM12 matches the images against spm12/tpm/TPM.nii , which is a set of tissue probability maps encoding GM, WM, CSF, bone(ish) soft-tissue(ish) and air.  It does not use a simple mutual information (or normalised mutual information) objective function.

Best regards,
-John



On Wed, 29 Aug 2018 at 18:20, Dianne Patterson <[log in to unmask]> wrote:
Dear Group,
I am comparing normalization of lesioned T1w images across various tools (spm, fsl, ants) with different options.  

I would like to compare the similarity of the resulting images in MNI space using Normalized Mutual Information (following Dohmatob 2018).  My concern is that I'm not sure what template spm12 is normalizing to. We don't choose it as an option in the GUI.  I do not see it listed in the resulting *job.m file.  I started digging through the matlabbatch code, but there is a lot of it. I would appreciate any pointers.  

I am normalizing the brains to fsl/data/standard/MNI152_T1_2mm_brain.nii.gz when I run normalization in ants and fsl. But what am I normalizing to in spm12?

Thanks so much,

Dianne
--
Dianne Patterson, Ph.D.
Research Scientist
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--
Prof John Ashburner
Professor of Imaging Science
UCL Institute of Neurology
Queen Square
Wellcome Trust Centre for Neuroimaging
University College London
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