Hi Maarten,

Thank you for your help!

| You would feed the denoised subject-space data into any further (nuisance) regression you would carry out. You could choose to do WM, CSF first, and then run your 'real' model, or include CSF and WM in your model.

If I decide to regress out WM and CSF first before running my real model, I will not need to regress out the ICA noise components as well, right? I think it's common to regress out motion regressors as well, that's why I'm asking.

| That choice goes back to the aggressive vs. non-aggressive denoising.

Would regressing out WM and CSF prior to the 1st level model be a type of aggressive or non-aggressive denoising?

Thanks,
Ben