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Good to see some numbers added Juan.

In this post I did it in a narrative way https://www.jiscmail.ac.uk/cgi-bin/webadmin?A2=ind1801&L=EVIDENCE-BASED-HEALTH&F=&S=&P=39385

The issue is that (young) people must not get the impression that they are protected against cervical-, mouth-, larynx-, or anal cancer by having had a "HPV vaccine".
People need to know that there are more HPV viruses than those covered by one of the HPV vaccines.

The information available does not inform about issues that I think are important "patient relevant outcomes" but rather mostly vaccine (industry) relevant outcomes?
For me as a GP (family doctor) the important issue is information to support shared decision making (SDM).

I think the following issues are important:

Do the discussions consider that are over 170 types HPV. "An HPV infection is caused by human papillomavirus, a DNA virus from the papillomavirus family, 
of which over 170 types are known.[7] More than 40 types are transmitted through sexual contact and infect the anus and genitals." "About a dozen HPV types (including types 16, 18, 31, and 45) are called "high-risk" types because persistent infection has been linked to cancers
such as cancer of the oropharynx, larynx, vulva, vagina, cervix, penis, and anus." https://en.wikipedia.org/wiki/Human_papillomavirus_infection#Cancer As such do the discussions mention that those vaccinated should not have assurance that they won't get any of the HPV types mentioned cancers? Do the discussions mention that due to the used HPV vaccines, others strains could now start the emerge as dominant cancer inducing HPV strains? Gardasil is quadrivalent vaccine, Cervarix is bivalent, and Gardasil is directed against 9 HPV https://en.wikipedia.org/wiki/Human_papillomavirus_infection#Vaccines Do the SDM discussions mention waning, how long does the vaccine provide cover for 2,4,resp 9 HPV types
(as e.g. MMR is now also suggested as a travel vaccine booster)? (according to the Green book probably repeat needed after 10 yrs) Ultimately these issues are "patient relevant" that need to inform doctors and school nurses, so that they can share this with the teenager, as part of shared decision making. And as a rhetorical question, are these patient important issues discussed to enable SDM in schools and medical facilities? https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/317821/Green_Book_Chapter_18a.pdf


Wouter Havinga, locum GP South West England, UK


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