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Thank you Vasiliy for your reply. 

I have posted some of Ioannidis articles here! In fact, one of my favorite researchers. 

My question simply is the recommendation of consumption of fruits and vegetables has any merit considering most of the evidence comes from observational evidence too?. And these are are federal guidelines making strong recommendations and even endorsed by WHO. Should we stop making these strong recommendations if the evidence is not clear? Or should we keep eating these because there "maybe" be a benefit?

And most of his recommendations about sensitivity analysis, data sharing, looking at totality applies to every observational study, not just nutrition epi. 


On Mon, Aug 27, 2018 at 2:12 PM, Vasiliy Vlassov <[log in to unmask]> wrote:
Dear Anoop,

this is not the first time JPAI address the nutrition research. The more detailed analyses were published already.

After the decades of the recommendations not eat cholesterol, continuing scandal with 'Mediterranean diet' (equal to added olive oil and nuts), decades of muddling with vitamin В all reasonable epidemiologists/public health specialists should start to think. The recipe prescribed by JPAI is well thought, and probably more positive than the one I have in mind.

Your question is the understatement. We should not question the 'general advice' but we should speak aloud again and again that most advice is malinformed, including influence from the industry, and should be reconsidered.

Thanks, JPAI, for persistence in this

VVV



On 2018-08-26 00:16, Anoop Balachandran wrote:
Ioannidis is back with some stinging rebuke of nutritional epidemiology:https://jamanetwork.com/journals/jama/fullarticle/2698337

My question is so should we question the general advice of eating vegetables, fruits and minimizing red meat to stay healthy?

Some of his recommendations: "Data from existing cohorts should become available for reanalysis by independent investigators. Their results should be presented in their totality for all nutritional factors measured, with standardized methods and standardized exploration of the sensitivity of conclusions to model and analysis choices. Readers and guideline developers may ignore hasty statements of causal inference and advocacy to public policy made by past nutritional epidemiology articles."

And I would say his recommendations are equally applicable to most observational studies, if not all. Nutritional research happen to get more attention and may have greater measurement issues than other areas.

Any thoughts?

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Vasiliy V. Vlassov, MD
Professor, National Research University Higher School of Economics
e-mail: vlassov[a t]cochrane.ru
Web page https://www.hse.ru/en/org/persons/14527416
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