There is a BSG guideline on the management of abnormal LFT, published in Gut in January, (https://gut.bmj.com/content/67/1/6 ) which states:

 

Recommendation 1: Initial investigation for

potential liver disease should include bilirubin,

albumin, alanine aminotransferase (ALT), alkaline

phosphatase (ALP) and ã-glutamyltransferase

(GGT), together with a full blood count

if not already performed within the previous 12

months.

 

We don’t routinely do GGT, but add it on when we review results and it seems relevant.

 

 

Hi mailbase

 

I  would also  be interested in knowing What do you include in your LFT profile? Also are there any national guidelines?

Our LFTs profile -

Total Bilirubin

ALT

AST
ALP
Albumin

 

NO total protein – removed about two year ago

 

Would be interested to hear if any labs have deleted AST from their LFT profile , any pros or cons to this.

 

 

 

 

Good morning Mailbase,

 

Today I have two questions for you:

 

​​​What do you include in your LFT profile? More specifically, does it include total protein?

 

Do you measure osmolality in both serum and plasma? In my understanding, theoretically, there should be no difference, but we have seen significant positive bias in plasma samples compared with serum in the normal range. Anecdotally I know of a couple of other labs who have found the same and I'd be interested to know the general opinion (if there is one!).

 

As ever, all responses greatly appreciated and I will summarise if I get a few.

 

Best wishes,

 

Helen

 

Helen Jerina PhD

 

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