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Dear CAT12 expert, 

I am performing a VBM longitudinal studies on stroke patients and I´m having issues in the segmentation step in one of them.  For preprocessing I have introduced the T1 image with the  lesion areas set to zero (lesion masked). 
The error I find is " Error using cat_main_gintnorm (line 376)"

I have also run the segmentation on the T1 image without taking out the lesion and runs well but I understand this will be less accurate due to tissue misclassification 

Any idea on how may I solve this? 

Thank you in advance 

Best 

Maria Jose  

  Running 'Longitudinal Rigid Registration'
Estimated noise sd for "F:\VBM_10patientsDone\P09\p09_t1\P09_T1_masked.img,1" = 9.04208
Estimated noise sd for "F:\VBM_10patientsDone\P09\p09_t2\P09_T1_masked.img,1" = 10.5562
Estimated noise sd for "F:\VBM_10patientsDone\P09\p09_t3\P09_T3_masked.img,1" = 8.92616
APP:                                                              
  Initialize                                                          4s
  Estimate background                                                 5s
  Initial correction                                                  2s
  Refine background                                                   6s
  Final correction                                                    2s
  Final scaling                                                       9s
    APP-noise ~ 16%, APP-bias ~ 57% (BWP-level), APP-inv ~ 0.00
  55s
Done    'Longitudinal Rigid Registration'
Running 'CAT12: Segmentation'

------------------------------------------------------------------------
CAT12.3 r1318: 1/1: F:\VBM_10patientsDone\P09\p09_t1\avg_P09_T1_masked.n
------------------------------------------------------------------------
SANLM denoising (NCstr=-Inf):                                        38s
APP: Rough bias correction:                                       
  Initialize                                                         10s
  Estimate background                                                 9s
  Initial correction                                                 14s
  Refine background                                                  12s
  Final correction                                                   11s
  Background correction                                               1s
  Final scaling                                                       3s
                                                                     60s
Coarse affine registration                                            8s
Affine registration                                                  18s
SPM preprocessing 1 (estimate):                                     446s
SPM preprocessing 2 (write):                                         88s
Global intensity correction:                                      
------------------------------------------------------------------------
CAT Preprocessing error for avg_P09_T1_masked:
------------------------------------------------------------------------
Bad tissue contrast (C=373.01, G=690.27, W=-0.14)

------------------------------------------------------------------------
  376 - cat_main_gintnorm
  526 - cat_main
  674 - cat_run_job1070
   16 - cat_run_newcatch
  392 - run_job
  161 - cat_run
   29 - cfg_run_cm
 1688 - local_runcj
  959 - cfg_util
  469 - fill_run_job
  247 - spm_jobman
   53 - cat_long_multi_run
   29 - cfg_run_cm
 1688 - local_runcj
  959 - cfg_util
  703 - MenuFileRun_Callback
   95 - gui_mainfcn
   53 - cfg_ui
------------------------------------------------------------------------
  Warning:cat_io_report:CATgui: Incomplete report creation in cat_io_report because of incomplete CAT parameters.

Print 'Graphics' figure to: 
  F:\VBM_10patientsDone\P09\p09_t1\report\catreport_avg_P09_T1_masked.pdf
Failed  'CAT12: Segmentation'
Error using cat_main_gintnorm (line 376)
Bad tissue contrast (C=373.01, G=690.27, W=-0.14)