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Hi Aaron, The contrast in the randomise manual is the one you should use: it will capture both positive and negative effects as the F-test is bidirectional (two-tailed). The alternative you suggest won't work I'm afraid as that contrast is rank-deficient, i.e., it has rank 3, not 5 or 6, meaning that some of the lines don't test anything extra that isn't already present in the others (well, it may in fact work in randomise because behind the scenes it removes redundancies but this is because the implementation is nice with the user; the same may not work in other software). Regarding missing subjects, it also works in randomise as in the example, just make sure each subject is in their own exchangeability block. All the best, Anderson On Wed, 25 Jul 2018 at 14:43, Tanenbaum, Aaron <[log in to unmask]> wrote: > I have two questions. First, I am trying to do a repeated measures anova. > I have a few subjects that have missing time points. I was wondering can > randomise handle this. Second, in terms of the contrast file using > https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Randomise/UserGuide as an example. > In this webpage it says the contrast file for the repeated measures anova > should be > > > 0 0 1 0 0 > 0 0 0 1 0 > 0 0 0 0 1 > > > However, this only captures positive differences from the reference level. > Because, I am looking for both positive and negative difference i was > thinking the contrast file should look like. > > > 0 0 1 0 0 > 0 0 0 1 0 > 0 0 0 0 1 > > 0 0 -1 0 0 > 0 0 0 -1 0 > 0 0 0 0 -1 > > > Am I getting this correct or am I completely wrong? > > > Aaron Tanenbaum > > > ------------------------------ > > The materials in this message are private and may contain Protected > Healthcare Information or other information of a sensitive nature. If you > are not the intended recipient, be advised that any unauthorized use, > disclosure, copying or the taking of any action in reliance on the contents > of this information is strictly prohibited. If you have received this email > in error, please immediately notify the sender via telephone or return mail. > > ------------------------------ > > To unsubscribe from the FSL list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=FSL&A=1 > ######################################################################## To unsubscribe from the FSL list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=FSL&A=1