That was my interpretation too Angela.
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On Tue, 24 Jul 2018 at 15:32, KREMMYDA, Angela (SHREWSBURY AND TELFORD HOSPITAL NHS TRUST)<[log in to unmask]> wrote: #yiv5606982041 #yiv5606982041 -- _filtered #yiv5606982041 {font-family:Calibri;panose-1:2 15 5 2 2 2 4 3 2 4;} _filtered #yiv5606982041 {font-family:Tahoma;panose-1:2 11 6 4 3 5 4 4 2 4;} _filtered #yiv5606982041 {font-family:Harrington;panose-1:4 4 5 5 5 10 2 2 7 2;} _filtered #yiv5606982041 {font-family:MT;panose-1:3 4 6 2 4 6 7 8 9 4;} _filtered #yiv5606982041 {font-family:Sans;panose-1:3 15 7 2 3 3 2 2 2 4;} _filtered #yiv5606982041 {font-family:Webdings;panose-1:5 3 1 2 1 5 9 6 7 3;}#yiv5606982041 #yiv5606982041 p.yiv5606982041MsoNormal, #yiv5606982041 li.yiv5606982041MsoNormal, #yiv5606982041 div.yiv5606982041MsoNormal {margin:0cm;margin-bottom:.0001pt;font-size:11.0pt;}#yiv5606982041 a:link, #yiv5606982041 span.yiv5606982041MsoHyperlink {color:blue;text-decoration:underline;}#yiv5606982041 a:visited, #yiv5606982041 span.yiv5606982041MsoHyperlinkFollowed {color:purple;text-decoration:underline;}#yiv5606982041 p.yiv5606982041MsoPlainText, #yiv5606982041 li.yiv5606982041MsoPlainText, #yiv5606982041 div.yiv5606982041MsoPlainText {margin:0cm;margin-bottom:.0001pt;font-size:11.0pt;}#yiv5606982041 span.yiv5606982041PlainTextChar {}#yiv5606982041 .yiv5606982041MsoChpDefault {} _filtered #yiv5606982041 {margin:72.0pt 72.0pt 72.0pt 72.0pt;}#yiv5606982041 div.yiv5606982041WordSection1 {}#yiv5606982041
Can I ask - since it's the colour of the drug that interferes, am I right in thinking that the creatinine interference will only be in Jaffe methods, while enzymatic ones should be OK?
Angela
Angela Kremmyda DipRCPath
Principal Clinical Scientist (Biochemistry)
Shrewsbury & Telford Hospital NHS Trust
Tel: 01952 641222 x4368
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Hi Janice,
Thank you Pauline for bringing this discussion to my attention.
I am one of the authors in the Choy et al. 2016 paper cited in the MHRA guidelines.
Looking at the references cited by MHRA, Cardamone et al. were the first group to report on Beckman DxC.
My institution was using Beckman DxC (we later moved to Beckman AU) and we investigated on five commonly used instruments (Beckman AU, Beckman DxC, Roche, Siemens, Abbott) in Australia by spiking studies. We observed different interferences between actual patient samples and spiking studies, when analysed on multiple instruments - we wonder about drug METABOLITE interference.
Gounden and Zhao looked at Roche.
The drug manufacturer did their own experiment - I suggest interpret their findings with caution - do your own experiment.http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2015-0473-LE
Interference is unlikely at routine dose (up to 75 mg). Interference observed at trial doses (200 mg or 300 mg).
The colour of the drug in solution changes with pH - imagine what happens with bilirubin diazo assays.
Beckman AU bilirubin assay is resistant to interference because, unlike other assays, it has two channels - the colour change (due to pH change) cancels out each other. How clever is the manufacturer.
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