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Hi Amy, interesting you should mention this: We've recently started seeing more discrepancies between our A.fumigatus precipitating antibody assay (counter-current immunoelectrophoresis method) and the A.fumigatus IgG FEIA on the ImmunoCAP. I'll investigate whether it coincides with these lot numbers and let you know. Basically we're seeing mild/moderately elevated A.fumigatus specific IgG results on the ImmunoCAP (values typically 50-100) with completely negative CIE results (tested for precipitins to both A.fumigatus filtrate and somatic antigens). We would expect negative CIE results to generate a corresponding A.fumigatus IgG result <40. thanks, Adrian Dr Adrian Heaps BSc MSc PhD DIC FRCPath Consultant Clinical Scientist & Clinical Lead for Immunology Department of Virology & Immunology Cumberland Infirmary Newtown Road Carlisle Cumbria CA2 7HY Cumberland Infirmary contact: [log in to unmask]<mailto:[log in to unmask]> Tel: 01228 814367 / 814645 Fax: 01228 814864 CIC bleep 704 The NCUHT Pathology Handbook can be found here<http://F-EMAIL01.xnuth.nhs.uk:32224/?dmVyPTEuMDAxJiY0YjY5NDU3OWQzNmUzNzJkMT01QjMyMTJFM18yODkyMl8xNDk5XzEmJmMzNTY5OWI0ZGI2YzZmOT0xMjIyJiZ1cmw9aHR0cCUzQSUyRiUyRnd3dyUyRW5jdWglMkVuaHMlMkV1ayUyRmZvci1ncHMlMkZwYXRob2xvZ3klMkZpbmRleCUyRWFzcHg=> James Cook University Hospital contact: [log in to unmask]<mailto:[log in to unmask]> Tel: 01642 854129 / 835642 ** Please note I work at the RVI Newcastle on Mondays ** Royal Victoria Infirmary, Newcastle contact: [log in to unmask]<mailto:[log in to unmask]> ________________________________ From: Clinical biochemistry discussion list [[log in to unmask]] on behalf of KILEY, Amy (DONCASTER AND BASSETLAW TEACHING HOSPITALS NHS FOUNDATION TRUST) [[log in to unmask]] Sent: 28 June 2018 14:56 To: [log in to unmask] Subject: Phadia Immunocap IgG Aspergillus Precipitins Hi all, We have switched to a new lot of Immunocap specific IgA/IgG sample diluent (box lot no. L06U, bottle lot no. AJLCH), and noticed an approximate 20% increase in our IgG Aspergillus precipitins in-house pooled patient QC as well as patient/EQA results. There has not been a shift in the kit QCs. Has anyone else moved to this new lot and seen a similar shift? Thanks in advance, Amy Amy Kiley Principal Clinical Biochemist Clinical Laboratory Sciences Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust Doncaster Royal Infirmary, Armthorpe Road, Doncaster DN2 5LT [cid:image003.jpg@01D3E920.81D68020] 01302 642841 [log in to unmask]<mailto:[log in to unmask]> This email is confidential, private and privileged. If you are not the intended recipient please accept our apologies. Do not disclose copy or distribute information in this email or take any action in reliance on its contents; to do so is strictly prohibited and may be unlawful. Please inform us that this email has gone astray before deleting it. 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For more information and to find out how you can switch, https://portal.nhs.net/help/joiningnhsmail ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ________________________________ CONFIDENTIALITY AND DISCLAIMER NOTICE This email and its attachments may be confidential and are intended solely for the use of the intended recipient. If you are not the intended recipient of this email and its attachments, you must take no action based upon them, nor must you copy or show them to anyone. Please contact the sender if you believe you have received this email in error. Any views or opinions expressed are solely those of the author and do not necessarily represent those of North Cumbria University Hospitals NHS Trust. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/