It should not be necessary to re align the HCP data. Peace, Matt. On 5/8/18, 6:06 AM, "FSL - FMRIB's Software Library on behalf of Jonathan Bain" <[log in to unmask] on behalf of [log in to unmask]> wrote: >Hi Matt, >Thanks for the advice. I started to rerun my analysis using the >--meshspace=caret framework, as you suggested. I was in the process of >making everything in HCP space when I realized that for the problematic >subjects, the alignment between diffusion/structural/freesurfer spaces >was bad. I decided to add skull-stripping to the pipeline before the >alignment, and now for all subjects the alignment is good, and the >subsequent analyses also work. >Thanks for your help! >Best, >Jonathan