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Hi Christian, Thank you very much for your suggestion. I might try it later (if the Reorient in SPM12 does not work, or not as good as the suggest tool). Regards, Suhuai -----Original Message----- From: SPM (Statistical Parametric Mapping) [mailto:[log in to unmask]] On Behalf Of Christian Gaser Sent: Thursday, 22 March 2018 6:48 PM To: [log in to unmask] Subject: Re: [SPM] How to make SPM12 Segment work to get Grey Matter etc. - Re-posted Dear Suhuai, you might also try the attached tool that uses center of mass to roughly correct the origin. Best, Christian >Hi Barbara, > >Thank you very much, I will try it. (Currently I am also thinking of using programming language to manipulate the data/images. Will see.) > > >Regards, > >Suhuai