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Course Title: Statistical Analysis of Genetic Association Studies Course Dates: 8 - 11 May 2018 Course Location: University of Liverpool Course Organiser: Dr Andrea Jorgensen Cost: £325 Places available: 20 Registration: https://payments.liv.ac.uk/conferences-and-events/events-at-liverpool/institute-of-translational-medicine/analysis-of-genetic-association-studies-course This four day course provides guidance on how to undertake the statistical analysis of a genetic association study, with particular focus on genome-wide association studies (GWAS). It provides an overview of the key statistical issues to be aware of when analysing genetic association studies, and an introduction to software for conducting the analyses. The course is structured to include a combination of short lectures and computer practicals to ensure that attendees gain hands-on experience of analysing genetic association datasets. It is delivered by the Statistical Genetics and Pharmacogenetics Research Group, University of Liverpool (https://www.liverpool.ac.uk/translational-medicine/research/statistical-genetics/). Who should attend ? The course is aimed at NHS professionals, PhD students and academic staff as well as individuals working elsewhere e.g. in industry with an interest in learning how to analyse genetic association studies. A prior understanding of basic statistical concepts would be an advantage (e.g. please see our week-long course ‘Statistical issues in the design and analysis of research projects’). What does the course cover ? * Introduction to R and linux * Genotype quality control * Introduction to genetic data * Population structure * Genotype calling * Genotype imputation * GWAS design and analysis * Software e.g. PLINK, SNPTest * Linkage disequilibrium Seminar The course will also include a seminar by Professor Andrew Morris, to reflect on real-life application of the theoretical concepts being taught. Andrew is Professor of Statistical Genetics in the Department of Biostatistics. The primary theme of his research is development, evaluation and application of methodology for analysis of GWAS and re-sequencing studies of complex human phenotypes, with focus on type 2 diabetes and related metabolic traits. He currently co-leads analytical groups in international efforts to further understanding of the genetic architecture and pathophysiology of type 2 diabetes as part of the DIAGRAM and DIAMANTE Consortia, which have led to identification of more than 100 loci robustly associated with the disease. Further information: For further information please contact Dr Andrea Jorgensen ([log in to unmask]) Dr Andrea L Jorgensen Senior Lecturer in Biostatistics Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, Liverpool, L69 3GL Website: https://www.liverpool.ac.uk/translational-medicine/research/statistical-genetics/about/ Tel: 0151 794 9739 You may leave the list at any time by sending the command SIGNOFF allstat to [log in to unmask], leaving the subject line blank.