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Chemical Information and Computation 2017, Number Two. 254th ACS National Meeting and Exposition, Washington, DC, August 20-24, 2017 Pleased to announce the publication of my fiftieth report in this series! It starts with the usual news section covering people, awards, and industry news, and recent developments at over 60 organizations in the computational chemistry, cheminformatics, chemical information, and publishing markets. Among other topical items, it also has detailed transcripts of technical presentations in symposia entitled "What do Synthetic Chemists Want from Their Reaction Systems?" and "Markush 360. Current and Future of Generic Structures in Chemical Patent Creation, Search and Analysis". Appendices include a report on the Herman Skolnik Award symposium (honoring David Winkler), and a poster on in silico synthesis guided by chemical transforms obtained through bootstrapping reaction databases. Order forms at http://www.warr.com<http://www.warr.com/>. Contents list at http://www.warr.com/morepubs.html. Wendy Dr. Wendy A. Warr Wendy Warr & Associates 6 Berwick Court, Holmes Chapel Cheshire, CW4 7HZ, England Tel./Fax +44 (0)1477 533837 [log in to unmask]<mailto:[log in to unmask]> http://orcid.org/0000-0002-7064-4739 http://www.warr.com<http://www.warr.com/> Skype: wendyannewarr Twitter: @WendyAnneWarr